Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas.

doi:10.1172/JCI115186

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas.

The Journal of clinical investigation - 1 May 1991

Khosla S, Patel V M, Hay I D, Schaid D J, Grant C S, van Heerden J A, Thibodeau S N

Abstract excerpt

Loss of heterozygosity (LOH) at specific loci may help localize tumor suppressor genes involved in the formation of various familial and sporadic tumors. In addition, the genetic loci for a number of familial tumor syndromes have been mapped by linkage analysis. To explore the possible role of tumor suppressor genes in endocrine tumors, we tested 41 pheochromocytomas (34 sporadic and 7 familial) and 11 medullary...

Topics

Adolescent
Adrenal Gland Neoplasms
Adult
Aged
Alleles
Carcinoma
Child
Chromosome Deletion
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 17
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Male

Middle Aged

Pheochromocytoma

Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 2022740
DOI: 10.1172/JCI115186
PMCID: PMC295269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2022740-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas.PMID 2022740Read ↗

Sporadic and familial pheochromocytomas are associated with loss of at least two discrete intervals on chromosome 1p.Semantic proximity Read ↗

Differential Genetic Alterations in von Hippel-Lindau Syndrome-Associated and Sporadic Pheochromocytomas1Semantic proximity Read ↗

Genetic events in tumour initiation and progression in multiple endocrine neoplasia type 2.Semantic proximity Read ↗

Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma.Semantic proximity Read ↗

Intra-tumoral molecular heterogeneity in benign and malignant pheochromocytomas and extra-adrenal sympathetic paragangliomas.Semantic proximity Read ↗

Loss of heterozygosity at the RET protooncogene locus in a case of multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

Frequent loss of heterozygosity at 6q in pheochromocytoma.Semantic proximity Read ↗

Common genetic changes in hereditary and sporadic pituitary adenomas detected by comparative genomic hybridizationSemantic proximity Read ↗

Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.Semantic proximity Read ↗

Deletion of chromosome 1, but not mutation of MEN-1, predicts prognosis in sporadic pancreatic endocrine tumors.Semantic proximity Read ↗

Deletion mapping on the distal third region of chromosome 1p in multiple endocrine neoplasia type IIA.Semantic proximity Read ↗

Genotyping of adrenocortical tumors: very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.