Article
High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas.
The Journal of clinical endocrinology and metabolism - 1 Jan 2006
Sarquis Marta S, Weber Frank, Shen Lei, Broelsch Christoph E, Jhiang Sissy M, Zedenius Jan, Frilling Andrea, Eng Charis
Abstract excerpt
CONTEXT: Many mammalian genes that are imprinted regulate cell growth, differentiation, and apoptosis. Because imprinting silences one of the two alleles, resulting in functional haploinsufficiency, we hypothesized that loss of heterozygosity (LOH) at an imprinted locus may result in the deletion of the only functional copy of an imprinted tumor suppressor gene. OBJECTIVE: The goal of this study was to...
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