A frequent mutation/polymorphism in tumor suppressor gene INK4B (MTS-2) in papillary and medullary thyroid cancer.

doi:10.1016/s0039-6060(96)80059-6

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Article

A frequent mutation/polymorphism in tumor suppressor gene INK4B (MTS-2) in papillary and medullary thyroid cancer.

Surgery - 1 Dec 1996

Goretzki P E, Gorelov V, Dotzenrath C, Witte J, Roeher H D

Abstract excerpt

BACKGROUND: Structural genetic changes of tumor suppressor genes MTS-1/INK4A and MTS-2/INK4B were demonstrated in a variety of human cancers but not in thyroid cancer until now. METHODS: Because MTS-2 encodes the tumor suppressor p15, a protein related to the transforming growth factor-beta inhib...

Topics

Adult
Carcinoma
Carcinoma, Medullary
Carcinoma, Papillary
Genes, Tumor Suppressor
Humans
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
Thyroid Neoplasms

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