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Article

Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors.

Gastroenterology - 1 Apr 1996

Naumann M, Savitskaia N, Eilert C, Schramm A, Kalthoff H, Schmiegel W

Abstract excerpt

BACKGROUND & AIMS: Cell-cycle inhibitor and tumor-suppressor gene p16/MTS1 was found to be altered in a variety of human tumors. To directly investigate genetic alterations and expression of p16/MTS1 and p15/MTS2, this study surveyed pancreatic tumors. METHODS: Cell-cycle inhibitors were analyzed for genetic alterations and expression by polymerase chain reaction, DNA sequencing, reverse-transcription polymerase...

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Source

Identifiers

PMID: 8613012
DOI: 10.1053/gast.1996.v110.pm8613012

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