Article
Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands.
European journal of immunology - 1 Oct 1998
Dörner T, Foster S J, Farner N L, Lipsky P E
Abstract excerpt
The impact of the somatic hypermutational machinery was examined by analyzing the frequency and distribution of mutations in nonproductive V(H)DJ(H) rearrangements obtained from individual human peripheral B cells. A strong bias toward nucleotide substitutions within the quadruplet motif RGYW was observed. In addition, there was a comparably increased frequency of mutations of the inverse repeat of RGYW, WRCY....
Topics
- Base Sequence
- Binding Sites
- DNA
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Molecular Sequence Data
- Mutation
- Repetitive Sequences, Nucleic Acid
- Trinucleotide Repeats