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Article

Somatic hypermutagenesis in immunoglobulin genes. I. Correlation between somatic mutations and repeats. Somatic mutation properties and clonal selection.

Biochimica et biophysica acta - 13 Jun 1991

Rogozin I B, Solovyov V V, Kolchanov N A

Abstract excerpt

Based on the analysis of some immunoglobulin V-gene sequences, somatic mutations are assumed to occur by correction of complementary violations in heteroduplexes formed by direct or inverted repeats. Correlation between somatic mutations and repeats is investigated by a statistical weights method in 323 somatic substitutions in 14 V-genes. Assuming absence of correlation, the probability of observing data in the...

Topics

Animals
B-Lymphocytes
Base Sequence
Genes, Immunoglobulin
Immunoglobulin Variable Region
Mice
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Nucleic Acid Heteroduplexes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 2054380
DOI: 10.1016/0167-4781(91)90005-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2054380-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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