Article
Somatic hypermutation of VkappaJkappa rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs.
European journal of immunology - 1 Dec 1999
Foster S J, Dörner T, Lipsky P E
Abstract excerpt
Productive and nonproductive VkappaJkappa gene rearrangements from individual peripheral blood B cells were analyzed for the pattern and distribution of mutations. The eight RGYW motifs and their inverse repeats, WRCY, were present in germ-line Vkappa genes significantly more often than anticipated by random chance (1.6-fold and 1.4-fold, respectively) and were also mutated in nonproductive rearrangements...
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