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Article

Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η.

Proceedings of the National Academy of Sciences of the United States of America - 14 May 2013

Zhao Ye, Gregory Mark T, Biertümpfel Christian, Hua Yue-Jin, Hanaoka Fumio, Yang Wei

Abstract excerpt

Somatic hypermutation is programmed base substitutions in the variable regions of Ig genes for high-affinity antibody generation. Two motifs, RGYW and WA (R, purine; Y, pyrimidine; W, A or T), have been found to be somatic hypermutation hotspots. Overwhelming evidence suggests that DNA polymerase η (Pol η) is responsible for converting the WA motif to WG by misincorporating dGTP opposite the templating T. To...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23630267
DOI: 10.1073/pnas.1303126110
PMCID: PMC3657764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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