Article
Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting.
Blood - 16 Apr 2009
Longo Nancy S, Lugar Patricia L, Yavuz Sule, Zhang Wen, Krijger Peter H L, Russ Daniel E, Jima Dereje D, Dave Sandeep S, Grammer Amrie C, Lipsky Peter E
Abstract excerpt
Subjects with X-linked hyper-IgM syndrome (X-HIgM) have a markedly reduced frequency of CD27(+) memory B cells, and their Ig genes have a low level of somatic hypermutation (SHM). To analyze the nature of SHM in X-HIgM, we sequenced 209 nonproductive and 926 productive Ig heavy chain genes. In nonproductive rearrangements that were not subjected to selection, as well as productive rearrangements, most of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.