Lack of correlation between repair of DNA interstrand cross-links and hypersensitivity of hamster cells towards mitomycin C and cisplatin.

doi:10.1016/s0014-5793(98)01209-5

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Article

Lack of correlation between repair of DNA interstrand cross-links and hypersensitivity of hamster cells towards mitomycin C and cisplatin.

FEBS letters - 16 Oct 1998

Larminat F, Cambois G, Zdzienicka M Z, Defais M

Abstract excerpt

The ability to repair DNA interstrand cross-links may be an important factor contributing to mitomycin C (MMC) and cisplatin cytotoxicities. We have assessed the repair of interstrand cross-links induced by MMC in two MMC-hypersensitive hamster cell mutants and their resistant parental cell line....

Topics

Animals
Cell Survival
Cells, Cultured
Cisplatin
Colony-Forming Units Assay
Cricetinae
Cricetulus
Cross-Linking Reagents
DNA Repair
Mitomycin
Mutation

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