Article
Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents.
Mutation research - 1 Sept 1991
Caldecott K, Jeggo P
Abstract excerpt
A range of hamster cell mutants, which have been characterised as sensitive to ionising radiation, were examined for their cross-sensitivity to four DNA-DNA cross-linking agents and the protein-DNA cross-linking agent, camptothecin. The mutants represent 7 distinct complementation groups. Two complementation groups were identified as having a major sensitivity to cross-linking damage, more marked than their...
Topics
- Animals
- CHO Cells
- Camptothecin
- Cell Line
- Cell Survival
- Cisplatin
- Cricetinae
- Cricetulus
- Cross-Linking Reagents
- DNA Damage
- Female
- Guinea Pigs