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Article

Mechanisms determining sensitivity to cisplatin in three mutant Chinese hamster ovary cell lines.

Mutation research - 1 Jun 1998

Segelov E, Mann G, deFazio A, Harnett P R

Abstract excerpt

To gain insight into factors determining the response of tumours to cisplatin, we studied pathways involved in resistance to cisplatin: drug uptake, cytoplasmic detoxification and DNA repair, in three cisplatin-sensitive Chinese hamster ovary (CHO)2 mutant cell lines. The mutant lines, CHO-MMC6, CHO-MMC1, CHO-MMS2, displayed inherent sensitivity to cisplatin (2.2, 4.1 and 10.6-fold, respectively) compared to the...

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PMID: 9653450
DOI: 10.1016/s0921-8777(98)00006-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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