Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of apoptosis in mitomycin C hypersensitivity of Chinese hamster cell mutants.

Biochemical pharmacology - 1 May 2000

Papouli E, Lafon C, Valette A, Zdzienicka M Z, Defais M, Larminat F

Abstract excerpt

To elucidate the mechanisms of the mammalian cell defense against cross-linking agents, we studied previously cellular responses to mitomycin C (MMC) treatment in two MMC-hypersensitive hamster cell mutants' V-H4 and V-C8, as well as their parental cell line V79. In the present report, we investigated whether alterations in cell cycle checkpoints and induction of apoptosis could be responsible for the MMC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to Apoptosis
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Cricetinae

Share to Cricetulus

Share to Mitomycin

Share to Mutation

Source

Identifiers

PMID: 10704939
DOI: 10.1016/s0006-2952(00)00234-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of apoptosis in mitomycin C hypersensitivity of Chinese hamster cell mutants.PMID 10704939Read ↗

Overexpression of metallothionein-II sensitizes rodent cells to apoptosis induced by DNA cross-linking agent through inhibition of NF-kappa B activation.Semantic proximity Read ↗

Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53.Semantic proximity Read ↗

Genetic diversity of mitomycin C-hypersensitive Chinese hamster cell mutants: a new complementation group with chromosomal instability.Semantic proximity Read ↗

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G2 checkpoint abrogationSemantic proximity Read ↗

Lack of correlation between repair of DNA interstrand cross-links and hypersensitivity of hamster cells towards mitomycin C and cisplatin.Semantic proximity Read ↗

A new complementation group of mitomycin C-hypersensitive Chinese hamster cell mutants that closely resembles the phenotype of fanconi anemia cells.Semantic proximity Read ↗

Isolation and partial characterisation of a mammalian cell mutant hypersensitive to topoisomerase II inhibitors and X-rays.Semantic proximity Read ↗

Chinese hamster cell mutant, V-C8, a model for analysis of Brca2 function.Semantic proximity Read ↗

Differential Toxicity of DNA Adducts of Mitomycin CSemantic proximity Read ↗

The Chinese hamster V79 cell mutant V-H4 is phenotypically like Fanconi anemia cells.Semantic proximity Read ↗

Dependence of the Cytotoxicity of DNA-Damaging Agents on the Mismatch Repair Status of Human CellsSemantic proximity Read ↗

Genetic analysis of mitomycin C-hypersensitive Chinese hamster cell mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.