Role of the human ERCC-1 gene in gene-specific repair of cisplatin-induced DNA damage.

doi:10.1093/nar/22.15.3005

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Article

Role of the human ERCC-1 gene in gene-specific repair of cisplatin-induced DNA damage.

Nucleic acids research - 11 Aug 1994

Larminat F, Bohr V A

Abstract excerpt

The human excision repair gene ERCC-1 gene restores normal resistance to UV and mitomycin C in excision repair deficient chinese hamster ovary cells of complementation group 1. To investigate the involvement of the ERCC-1 gene in gene-specific repair of bulky lesions, we have studied the removal...

Topics

Animals
CHO Cells
Cell Survival
Cisplatin
Cricetinae
Cross-Linking Reagents
DNA
DNA Damage
DNA Repair
DNA-Binding Proteins
Endonucleases
Humans
Mutation
Nucleic Acid Denaturation
Nucleic Acid Renaturation
Proteins
Tetrahydrofolate Dehydrogenase
Transfection

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