Article
Tolerance to O6-methylguanine and 6-thioguanine cytotoxic effects: a cross-resistant phenotype in N-methylnitrosourea-resistant Chinese hamster ovary cells.
Cancer research - 15 Jul 1990
Aquilina G, Giammarioli A M, Zijno A, Di Muccio A, Dogliotti E, Bignami M
Abstract excerpt
The biochemical and genetic characteristics of a clone of Chinese hamster ovary cells displaying resistance to N-methyl-N-nitrosourea (MNU) and 6-thioguanine (6-TG) were analyzed. The initial level of 7-methylguanine, 3-methyladenine, and O6-methylguanine formation and the repair rates for these...
Topics
- Alkylation
- Animals
- Cell Line
- Cell Survival
- Clone Cells
- Cricetinae
- Cricetulus
- DNA
- DNA Repair
- Drug Resistance
- Female
- Guanine
- Kinetics
- Methylnitrosourea
- Ovary
- Phenotype
- Sister Chromatid Exchange
- Thioguanine