Article
Inherent sensitivity and induced resistance to chemotherapeutic drugs and irradiation in human cancer cell lines: relationship to mutation frequencies.
Cancer research - 1 Dec 1990
Parris C N, Walker M C, Masters J R, Arlett C F
Abstract excerpt
Metastatic nonseminomatous testicular germ cell tumors are curable using combination chemotherapy in approximately 80% of patients. In contrast, most other patients with other types of cancer either present with or acquire drug-resistant disease following chemotherapy. Cell lines derived from tes...
Topics
- Antineoplastic Agents
- Cisplatin
- DNA
- Dose-Response Relationship, Drug
- Drug Resistance
- Ethyl Methanesulfonate
- Humans
- Hypoxanthine Phosphoribosyltransferase
- In Vitro Techniques
- Male
- Mutation
- Testicular Neoplasms
- Thioguanine
- Urinary Bladder Neoplasms