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Article

Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA.

The EMBO journal - 2 Nov 1998

Blaiseau P L, Thomas D

Abstract excerpt

The transcriptional regulation of the sulfur amino acid pathway in Saccharomyces cerevisiae depends on a single activator, Met4p, whose function requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p. The first description of how these factors cooperate to activate transcription was provided by the identification of the Cbf1-Met4-Met28 complex which is assembled on the...

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Identifiers

PMID: 9799240
DOI: 10.1093/emboj/17.21.6327
PMCID: PMC1170957

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA.PMID 9799240Read ↗

Characterizing the roles of Met31 and Met32 in coordinating Met4-activated transcription in the absence of Met30.Semantic proximity Read ↗

Single point mutations in Met4p impair the transcriptional repression of MET genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

The general amino acid control regulates MET4, which encodes a methionine-pathway-specific transcriptional activator of Saccharomyces cerevisiae.Semantic proximity Read ↗

Met30p, a yeast transcriptional inhibitor that responds to S-adenosylmethionine, is an essential protein with WD40 repeats.Semantic proximity Read ↗

A dominant suppressor mutation of the met30 cell cycle defect suggests regulation of the Saccharomyces cerevisiae Met4-Cbf1 transcription complex by Met32.Semantic proximity Read ↗

Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complex.Semantic proximity Read ↗

Yeast 14-3-3 protein functions as a comodulator of transcription by inhibiting coactivator functions.Semantic proximity Read ↗

A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo.Semantic proximity Read ↗

Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator.Semantic proximity Read ↗

Mediator, known as a coactivator, can act in transcription initiation in an activator-independent manner in vivo.Semantic proximity Read ↗

The DNA target sequence influences the dependence of the yeast transcriptional activator Gcn4 on co-factors.Semantic proximity Read ↗

Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions.Semantic proximity Read ↗

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