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Article

A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo.

Molecular and cellular biology - 1 Apr 2003

Swanson Mark J, Qiu Hongfang, Sumibcay Laarni, Krueger Anna, Kim Soon-ja, Natarajan Krishnamurthy, Yoon Sungpil, Hinnebusch Alan G

Abstract excerpt

Transcriptional activators interact with multisubunit coactivators that modify chromatin structure or recruit the general transcriptional machinery to their target genes. Budding yeast cells respond to amino acid starvation by inducing an activator of amino acid biosynthetic genes, Gcn4p. We conducted a comprehensive analysis of viable mutants affecting known coactivator subunits from the Saccharomyces Genome...

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Source

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Identifiers

PMID: 12665580
DOI: 10.1128/MCB.23.8.2800-2820.2003
PMCID: PMC152555

Genes

CCR4
ARG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo.PMID 12665580Read ↗

Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo.Semantic proximity Read ↗

An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p.Semantic proximity Read ↗

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.Semantic proximity Read ↗

Recruitment of SWI/SNF by Gcn4p does not require Snf2p or Gcn5p but depends strongly on SWI/SNF integrity, SRB mediator, and SAGA.Semantic proximity Read ↗

Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.Semantic proximity Read ↗

The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription.Semantic proximity Read ↗

Gcn4 Binding in Coding Regions Can Activate Internal and Canonical 5' Promoters in Yeast.Semantic proximity Read ↗

Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo.Semantic proximity Read ↗

Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes.Semantic proximity Read ↗

The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.Semantic proximity Read ↗

A triad of subunits from the Gal11/tail domain of Srb mediator is an in vivo target of transcriptional activator Gcn4p.Semantic proximity Read ↗

Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation.Semantic proximity Read ↗

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