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Article

Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complex.

The EMBO journal - 17 Jan 2000

Rouillon A, Barbey R, Patton E E, Tyers M, Thomas D

Abstract excerpt

Saccharomyces cerevisiae SCF(Met30) ubiquitin-protein ligase controls cell cycle function and sulfur amino acid metabolism. We report here that the SCF(Met30 )complex mediates the transcriptional repression of the MET gene network by triggering degradation of the transcriptional activator Met4p when intracellular S-adenosylmethionine (AdoMet) increases. This AdoMet-induced Met4p degradation is dependent upon the...

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Identifiers

PMID: 10637232
DOI: 10.1093/emboj/19.2.282
PMCID: PMC305562

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complex.PMID 10637232Read ↗

The abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability.Semantic proximity Read ↗

Met30p, a yeast transcriptional inhibitor that responds to S-adenosylmethionine, is an essential protein with WD40 repeats.Semantic proximity Read ↗

Identification of residues in the WD-40 repeat motif of the F-box protein Met30p required for interaction with its substrate Met4p.Semantic proximity Read ↗

SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition.Semantic proximity Read ↗

The amino-terminal portion of the F-box protein Met30p mediates its nuclear import and assimilation into an SCF complex.Semantic proximity Read ↗

A dominant suppressor mutation of the met30 cell cycle defect suggests regulation of the Saccharomyces cerevisiae Met4-Cbf1 transcription complex by Met32.Semantic proximity Read ↗

Cdc48 cofactor Shp1 regulates signal-induced SCFMet30 disassembly.Semantic proximity Read ↗

Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA.Semantic proximity Read ↗

The F-box protein Met30 is required for multiple steps in the budding yeast cell cycle.Semantic proximity Read ↗

Single point mutations in Met4p impair the transcriptional repression of MET genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism.Semantic proximity Read ↗

Characterizing the roles of Met31 and Met32 in coordinating Met4-activated transcription in the absence of Met30.Semantic proximity Read ↗

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