Article
Yeast 14-3-3 protein functions as a comodulator of transcription by inhibiting coactivator functions.
The Journal of biological chemistry - 19 Dec 2014
Parua Pabitra K, Dombek Kenneth M, Young Elton T
Abstract excerpt
In eukaryotes combinatorial activation of transcription is an important component of gene regulation. In the budding yeast Saccharomyces cerevisiae, Adr1-Cat8 and Adr1-Oaf1/Pip2 are pairs of activators that act together to regulate two diverse sets of genes. Transcription activation of both sets is regulated positively by the yeast AMP-activated protein kinase homolog, Snf1, in response to low glucose or the...
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