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Article

A dominant suppressor mutation of the met30 cell cycle defect suggests regulation of the Saccharomyces cerevisiae Met4-Cbf1 transcription complex by Met32.

The Journal of biological chemistry - 25 Apr 2008

Su Ning-Yuan, Ouni Ikram, Papagiannis Christie V, Kaiser Peter

Abstract excerpt

Met30 is the substrate recognition subunit of the essential ubiquitin ligase SCF(Met30). The essential function of Met30 is the inactivation of the Saccharomyces cerevisiae transcription factor Met4, because fully activated Met4 induces a cell cycle arrest. Met4 regulates expression of genes involved in the sulfur assimilation pathway and coordinates the transcriptional program and cell cycle progression in...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Identifiers

PMID: 18308733
DOI: 10.1074/jbc.M708230200
PMCID: PMC2431082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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A dominant suppressor mutation of the met30 cell cycle defect suggests regulation of the Saccharomyces cerevisiae Met4-Cbf1 transcription complex by Met32.PMID 18308733Read ↗

Characterizing the roles of Met31 and Met32 in coordinating Met4-activated transcription in the absence of Met30.Semantic proximity Read ↗

SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition.Semantic proximity Read ↗

Identification of residues in the WD-40 repeat motif of the F-box protein Met30p required for interaction with its substrate Met4p.Semantic proximity Read ↗

The F-box protein Met30 is required for multiple steps in the budding yeast cell cycle.Semantic proximity Read ↗

Met30p, a yeast transcriptional inhibitor that responds to S-adenosylmethionine, is an essential protein with WD40 repeats.Semantic proximity Read ↗

Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complex.Semantic proximity Read ↗

Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA.Semantic proximity Read ↗

Met32 governs transcriptional control of sulfur metabolic flexibility and resistance to reactive sulfur species in the human fungal pathogen <i>Candida albicans</i>Semantic proximity Read ↗

The abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability.Semantic proximity Read ↗

Single point mutations in Met4p impair the transcriptional repression of MET genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cdc48 cofactor Shp1 regulates signal-induced SCFMet30 disassembly.Semantic proximity Read ↗

The amino-terminal portion of the F-box protein Met30p mediates its nuclear import and assimilation into an SCF complex.Semantic proximity Read ↗

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