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Article

The DNA target sequence influences the dependence of the yeast transcriptional activator Gcn4 on co-factors.

Molecular & general genetics : MGG - 27 Feb 1997

Tavernarakis N, Thireos G

Abstract excerpt

The yeast transcriptional activator Gcn4 requires the Ada2/Gcn5/Ada3 co-activator complex to exert part of its activation potential. Here we show that the sequence of the DNA target modulates the function of Gcn4 by modifying this requirement. Promoter configurations were generated that rendered Gcn4-induced transcription either completely dependent or completely independent of the Ada2/Gcn5/Ada3 complex. The...

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PMID: 9079889
DOI: 10.1007/s004380050382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The DNA target sequence influences the dependence of the yeast transcriptional activator Gcn4 on co-factors.PMID 9079889Read ↗

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GCN5, a yeast transcriptional coactivator, induces chromatin reconfiguration of HIS3 promoter in vivo.Semantic proximity Read ↗

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Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.Semantic proximity Read ↗

ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.Semantic proximity Read ↗

Structure/functional properties of the yeast dual regulator protein NGG1 that are required for glucose repression.Semantic proximity Read ↗

Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4.Semantic proximity Read ↗

Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites.Semantic proximity Read ↗

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.Semantic proximity Read ↗

Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation.Semantic proximity Read ↗

Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity.Semantic proximity Read ↗

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