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Article

Mediator, known as a coactivator, can act in transcription initiation in an activator-independent manner in vivo.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Aug 2018

Jean-Jacques Hélène, Poh Siew Lay, Kuras Laurent

Abstract excerpt

Mediator is an evolutionarily conserved complex best known for its role as a coactivator responsible for transducing regulatory signals from DNA-bound activators to the basal RNA polymerase II (Pol II) machinery that initiates transcription from promoters of protein-encoding genes. By exploiting our in vivo activator-independent transcription assay in Saccharomyces cerevisiae, in combination with new temperature...

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Identifiers

PMID: 29990553
DOI: 10.1016/j.bbagrm.2018.07.001

Genes

CDK8

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Mediator, known as a coactivator, can act in transcription initiation in an activator-independent manner in vivo.PMID 29990553Read ↗

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