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Article

Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2006

Prathapam Tulsiram, Tegen Sarah, Oskarsson Thordur, Trumpp Andreas, Martin G Steven

Abstract excerpt

The transcription factor Myc plays a central role in the control of cellular proliferation. Myc expression is induced by growth factors in a pathway mediated by cellular Src (c-Src), but it is not clear whether Myc induction or activity is required for malignant transformation by activated Src. We introduced v-Src into a c-myc(-/-) derivative of Rat-1 fibroblasts and into 3T9 mouse fibroblasts harboring a...

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Identifiers

PMID: 16477001
DOI: 10.1073/pnas.0511186103
PMCID: PMC1413844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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