Article
[The RET gene in thyroid pathology].
Archives d'anatomie et de cytologie pathologiques - 1 Jan 1998
Michiels F M, Billaud M
Abstract excerpt
The RET proto-oncogene encodes a receptor tyrosine kinase which plays a crucial role during the embryonic development of the enteric nervous system and of the kidney. Cytogenetic analyses of papillary thyroid carcinoma (PTC), a neoplasm which originates from thyrocytes, have revealed that somatic rearrangements of the RET gene are involved in the etiology of a significant proportion of this tumour. Medullary...
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