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Article

Development of medullary thyroid carcinoma in transgenic mice expressing the <i>RET</i> protooncogene altered by a multiple endocrine neoplasia type 2A mutation

1 Apr 1997

Abstract excerpt

Multiple endocrine neoplasia type 2 (MEN 2) is a dominantly inherited cancer syndrome that comprises three clinical subtypes: MEN type 2A (MEN-2A), MEN type 2B (MEN-2B), and familial medullary thyroid carcinoma (FMTC). Medullary thyroid carcinoma (MTC), a malignant tumor arising from calcitonin-secreting thyroid C cells, is the cardinal disease feature of this syndrome, and mortality in affected MEN-2 patients is...

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Identifiers

PMID: 9096393
DOI: 10.1073/pnas.94.7.3330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Development of medullary thyroid carcinoma in transgenic mice expressing the <i>RET</i> protooncogene altered by a multiple endocrine neoplasia type 2A mutationPMID 9096393Read ↗

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