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Article

Selective Ablation of Tumor Suppressors in Parafollicular C Cells Elicits Medullary Thyroid Carcinoma.

The Journal of biological chemistry - 3 Mar 2017

Song Hai, Lin Chuwen, Yao Erica, Zhang Kuan, Li Xiaoling, Wu Qingzhe, Chuang Pao-Tien

Abstract excerpt

Among the four different types of thyroid cancer, treatment of medullary thyroid carcinoma poses a major challenge because of its propensity of early metastasis. To further investigate the molecular mechanisms of medullary thyroid carcinoma and discover candidates for targeted therapies, we developed a new mouse model of medullary thyroid carcinoma based on our CGRPCreER mouse line. This system enables gene...

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Identifiers

PMID: 28119454
DOI: 10.1074/jbc.M116.765727
PMCID: PMC5339769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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