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Article

Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets

21 Apr 2009

Abstract excerpt

Medullary thyroid carcinoma (MTC) is a rare tumour arising from neural crest-derived parafollicular C-cells. Metastatic MTC patients are incurable because the cancer does not respond to radiotherapy or chemotherapy. The REarranged during Transfection (RET) proto-oncogene plays a key role in the development of MTC. However, one-half of the sporadic MTC do not carry RET mutations. Mice models and early evidence...

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Identifiers

PMID: 19383830
DOI: 10.1677/jme-09-0024

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Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targetsPMID 19383830Read ↗

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