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Article

The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.

Cancer research - 15 Jun 2006

Iervolino Angela, Iuliano Rodolfo, Trapasso Francesco, Viglietto Giuseppe, Melillo Rosa Marina, Carlomagno Francesca, Santoro Massimo, Fusco Alfredo

Abstract excerpt

Thyroid cancer is frequently associated with the oncogenic conversion of the RET receptor tyrosine kinase. RET gene rearrangements, which lead to the generation of chimeric RET/papillary thyroid carcinoma (PTC) oncogenes, occur in PTC, whereas RET point mutations occur in familial multiple endocrine neoplasia type 2 (MEN2) and sporadic medullary thyroid carcinomas (MTC). We showed previously that the expression...

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Identifiers

PMID: 16778204
DOI: 10.1158/0008-5472.CAN-06-0228

Genes

RET
PTPRJ

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.PMID 16778204Read ↗

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