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Article

Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span.

Cell - 16 Oct 1998

Apfeld J, Kenyon C

Abstract excerpt

The insulin/IGF receptor homolog DAF-2 regulates the aging in C. elegans. Decreasing daf-2 activity causes fertile adults to remain active much longer than normal and to live more than twice as long. A more severe decrease in daf-2 function causes young larvae to enter a state of diapause rather than progressing to adulthood. We have asked which cells require daf-2 gene activity in order for the animal to develop...

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PMID: 9790527
DOI: 10.1016/s0092-8674(00)81751-1

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