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Article

Genes that regulate both development and longevity in Caenorhabditis elegans.

Genetics - 1 Apr 1995

Larsen P L, Albert P S, Riddle D L

Abstract excerpt

The nematode Caenorhabditis elegans responds to conditions of overcrowding and limited food by arresting development as a dauer larva. Genetic analysis of mutations that alter dauer larva formation (daf mutations) is presented along with an updated genetic pathway for dauer vs. nondauer development. Mutations in the daf-2 and daf-23 genes double adult life span, whereas mutations in four other dauer-constitutive...

Topics

Animals
Caenorhabditis elegans
Gene Expression Regulation, Developmental
Genes, Helminth
Heterozygote
Homozygote
Longevity
Mutation
Phenotype
Reproduction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7789761
DOI: 10.1093/genetics/139.4.1567
PMCID: PMC1206485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7789761-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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