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Article

A C. elegans mutant that lives twice as long as wild type.

Nature - 2 Dec 1993

Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R

Abstract excerpt

We have found that mutations in the gene daf-2 can cause fertile, active, adult Caenorhabditis elegans hermaphrodites to live more than twice as long as wild type. This lifespan extension, the largest yet reported in any organism, requires the activity of a second gene, daf-16. Both genes also regulate formation of the dauer larva, a developmentally arrested larval form that is induced by crowding and starvation...

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PMID: 8247153
DOI: 10.1038/366461a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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