Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of steroid hormone signaling on life span control by Caenorhabditis elegans insulin-like signaling.

G3 (Bethesda, Md.) - 20 May 2013

Dumas Kathleen J, Guo Chunfang, Shih Hung-Jen, Hu Patrick J

Abstract excerpt

Sterol-sensing nuclear receptors and insulin-like growth factor signaling play evolutionarily conserved roles in the control of aging. In the nematode Caenorhabditis elegans, bile acid-like steroid hormones known as dafachronic acids (DAs) influence longevity by binding to and regulating the activity of the conserved nuclear receptor DAF-12, and the insulin receptor (InsR) ortholog DAF-2 controls life span by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Genes, Helminth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ Cells

Share to Hormones

Share to Insulin

Share to Longevity

Share to Receptor, Insulin

Share to Steroids

Source

Open in PubMed Open full text

Identifiers

PMID: 23550118
DOI: 10.1534/g3.112.005116
PMCID: PMC3656731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of steroid hormone signaling on life span control by Caenorhabditis elegans insulin-like signaling.PMID 23550118Read ↗

Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan.Semantic proximity Read ↗

Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.Semantic proximity Read ↗

Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost.Semantic proximity Read ↗

DAF-16 target genes that control C. elegans life-span and metabolism.Semantic proximity Read ↗

DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs.Semantic proximity Read ↗

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.Semantic proximity Read ↗

Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway.Semantic proximity Read ↗

Transcriptome- and phenotype-based epistasis analysis in Caenorhabditis elegans reveals daf-16/FoxO-dependent and independent effects of daf-2/InsR in L1 starvation and recovery.Semantic proximity Read ↗

Regulation of C. elegans life-span by insulinlike signaling in the nervous system.Semantic proximity Read ↗

Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegansSemantic proximity Read ↗

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.Semantic proximity Read ↗

The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.