Article
Mutational analysis of N-RAS and GAP-related domain of the neurofibromatosis type 1 gene in chronic myelogenous leukemia.
Leukemia research - 1 Nov 1998
Garicochea B, Giorgi R, Odone V F, Dorlhiac-Llacer P E, Bendit I
Abstract excerpt
RAS mutations can be detected in a variable number of patients with myeloproliferative disorders such as myelodysplastic syndromes and acute myeloid leukemia, but are rare events in chronic myelogenous leukemia in chronic phase. However, there is good evidence supporting the involvement of RAS si...
Topics
- Adult
- Child
- Child, Preschool
- DNA Mutational Analysis
- GTPase-Activating Proteins
- Genes, Neurofibromatosis 1
- Genes, ras
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Proteins
- ras GTPase-Activating Proteins