Article
High frequency of RAS oncogene mutation in chronic myeloid leukemia patients with myeloblastoma.
Leukemia & lymphoma - 1 Apr 1994
Tanaka K, Takauchi K, Takechi M, Kyo T, Dohy H, Kamada N
Abstract excerpt
To determine the role of the mutated RAS oncogene during development into the blast phase, we sequentially analysed RAS oncogene mutations in the bone marrow of 27 patients with chronic myeloid leukemia (CML). DNA from CML patients in chronic and blast phases and nude mouse tumor DNA formed by a...
Topics
- 3T3 Cells
- Adult
- Animals
- Blast Crisis
- Codon
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Genes, ras
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid, Accelerated Phase
- Leukemia, Myeloid, Chronic-Phase
- Male
- Mice
- Mice, Nude
- Middle Aged
- Mutation