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High frequency of RAS oncogene mutation in chronic myeloid leukemia patients with myeloblastoma.

Leukemia & lymphoma - 1 Apr 1994

Tanaka K, Takauchi K, Takechi M, Kyo T, Dohy H, Kamada N

Abstract excerpt

To determine the role of the mutated RAS oncogene during development into the blast phase, we sequentially analysed RAS oncogene mutations in the bone marrow of 27 patients with chronic myeloid leukemia (CML). DNA from CML patients in chronic and blast phases and nude mouse tumor DNA formed by a tumorigenicity assay (in vivo selection assay) were subjected to the polymerase chain reaction (PCR) and...

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PMID: 8049652
DOI: 10.3109/10428199409056296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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