Article
Analysis of mutations and expression of GAP-related domain of the neurofibromatosis type 1 (NF1) gene in the progression of chronic myelogenous leukemia.
Leukemia - 1 Jun 1994
Nakai H, Misawa S, Horiike S, Taniwaki M, Seriu T, Shimazaki C, Fujii H, Maekawa T, Furukawa T, Abe T
Abstract excerpt
We investigated mutations in the GTPase activating protein-related domain of the neurofibromatosis type 1 gene (NF1-GRD) and its expression in each phase of chronic myelogenous leukemia (CML). Samples from 45 cases in chronic phase (CP), 41 in acute phase, and four CML cell lines were examined for mutations in the NF1-GRD by single-strand conformation polymorphism (SSCP) analysis and allele specific restriction...
Topics
- Alleles
- Base Sequence
- Codon
- DNA, Single-Stranded
- Exons
- Genes, Neurofibromatosis 1
- Genes, ras
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Molecular Sequence Data