Article
Neurofibromatosis 1 gene (NF1) mutation is a rare genetic event in myelodysplastic syndrome regardless of the disease progression.
International journal of hematology - 1 Apr 1995
Kaneko H, Horiike S, Nakai H, Ueda Y, Nakao M, Hirakawa K, Yokota S, Taniwaki M, Misawa S, Kashima K
Abstract excerpt
Neurofibromatosis 1 gene (NF1) is a tumor suppressor gene and the product of which down-regulates Nras protein by its GTPase activating protein-related domain (NF1-GRD). Although the incidence of NF1 mutation was reported to be rare in the chronic phase of myelodysplastic syndrome (MDS), there have been no previous reports on its configuration in patients showing the disease progression. We examined NF1 in 50...
Topics
- Base Sequence
- Disease Progression
- Exons
- Genes, Neurofibromatosis 1
- Molecular Sequence Data
- Mutation
- Myelodysplastic Syndromes
- Polymerase Chain Reaction