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Article

Absence of N-ras mutations in myeloid and lymphoid blast crisis of chronic myeloid leukemia.

Cancer research - 15 Jul 1994

Watzinger F, Gaiger A, Karlic H, Becher R, Pillwein K, Lion T

Abstract excerpt

Mutations within N-ras oncogene codons 12, 13, and 61 occur in approximately 25-30% of patients with acute nonlymphocytic leukemia and at a lower frequency (6-20%) in patients with acute lymphocytic leukemia. Moreover, N-ras mutations have been described in patients with chronic myeloid leukemia (CML) in blast crisis but have not been observed during the chronic phase of the disease. In view of the morphological...

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PMID: 8033117

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