Article
RAS mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia.
Blood - 15 Sept 1990
Hirsch-Ginsberg C, LeMaistre A C, Kantarjian H, Talpaz M, Cork A, Freireich E J, Trujillo J M, Lee M S, Stass S A
Abstract excerpt
Previous reports have indicated that mutations of the RAS oncogenes are not associated with the chronic phase of Philadelphia chromosome-positive chronic myelogenous leukemia (Ph1+ CML). However, further studies were needed to determine their association with Ph1- CML and chronic myelomonocytic l...
Topics
- Gene Rearrangement
- Humans
- Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
- Leukemia, Myelomonocytic, Chronic
- Mutation
- Prognosis
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcr
- Proto-Oncogene Proteins p21(ras)