Mutations within the FLR exon of NF1 are rare in myelodysplastic syndromes and acute myelocytic leukemias.

Article

Mutations within the FLR exon of NF1 are rare in myelodysplastic syndromes and acute myelocytic leukemias.

Leukemia - 1 Jul 1993

Ludwig L, Janssen J W, Schulz A S, Bartram C R

Abstract excerpt

A mutational hotspot in the neurofibromatosis 1 (NF1) gene has recently emerged from the analysis of different malignancies including one patient with myelodysplastic syndrome (MDS). In these cases, Lys 1423 in the GTPase-activating protein (GAP)-related domain of NF1 is substituted which causes...

Topics

Acute Disease
Base Sequence
DNA, Neoplasm
Genes, Neurofibromatosis 1
Humans
Leukemia, Myeloid
Molecular Sequence Data
Mutation
Myelodysplastic Syndromes
Oligodeoxyribonucleotides

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