Article
N-RAS activation in the terminal stage of undifferentiated chronic myeloproliferative disease.
International journal of hematology - 1 Aug 1992
Inokuchi K, Futaki M, Miyake K, Kuwabara T, Shinohara T, Dan K, Nomura T
Abstract excerpt
The relationship between activation of the N-RAS gene and the leukemic progression of undifferentiated chronic myeloproliferative disease (UCMPD) was investigated in a 71-year-old male. Hematologically, it was difficult to differentiate the UCMPD from chronic myelogenous leukemia. Chromosomal analysis revealed no Philadelphia chromosome (Ph1-), and DNA analysis revealed no BCR rearrangement (BCR-) either at the...
Topics
- Aged
- Cell Differentiation
- Chronic Disease
- Gene Expression Regulation, Neoplastic
- Gene Rearrangement
- Genes, ras
- Humans
- Male
- Mutation
- Myeloproliferative Disorders
- Polymerase Chain Reaction