Analysis of neurofibromatosis type 1 gene mutation in juvenile chronic myelogenous leukemia.

doi:10.1159/000040858

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Article

Analysis of neurofibromatosis type 1 gene mutation in juvenile chronic myelogenous leukemia.

Acta haematologica - 1 Jan 1998

Watanabe I, Horiuchi T, Hatta N, Matsumoto M, Koike K, Kojima S, Ohga S, Fujita S

Abstract excerpt

The neurofibromatosis type 1 (NF1) gene has been considered to be a tumor suppressor gene, since the NF1 gene product downregulates the ras oncogene product (p21(ras)). In addition, children with NF1 show an increased incidence of myelogenous leukemia, including juvenile chronic myelogenous leuke...

Topics

Female
Genes, Neurofibromatosis 1
Genes, Tumor Suppressor
Humans
Infant
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Male
Mutation
Polymerase Chain Reaction

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