Article
The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo.
Development (Cambridge, England) - 1 Nov 1998
Faust C, Lawson K A, Schork N J, Thiel B, Magnuson T
Abstract excerpt
We have characterized an induced mutation, called embryonic ectoderm development or eed, that disrupts A-P patterning of the mouse embryo during gastrulation. Positional cloning of this gene revealed it to be the highly conserved homologue of the Drosophila gene extra sex combs, which is required...
Topics
- Animals
- Cell Lineage
- Cell Movement
- Congenital Abnormalities
- Culture Techniques
- Drosophila Proteins
- Gastrula
- Histone-Lysine N-Methyltransferase
- In Situ Hybridization
- Insect Proteins
- Mesoderm
- Mice
- Mice, Mutant Strains
- Morphogenesis
- Mutation
- Polycomb Repressive Complex 1
- Polycomb Repressive Complex 2
- RNA, Messenger