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Article

Nodal cis-regulatory elements reveal epiblast and primitive endoderm heterogeneity in the peri-implantation mouse embryo.

Developmental biology - 15 Jan 2011

Granier Céline, Gurchenkov Vasily, Perea-Gomez Aitana, Camus Anne, Ott Sascha, Papanayotou Costis, Iranzo Julian, Moreau Anne, Reid John, Koentges Georgy, Sabéran-Djoneidi Délara, Collignon Jérôme

Abstract excerpt

Nodal, a secreted factor known for its conserved functions in cell-fate specification and the establishment of embryonic axes, is also required in mammals to maintain the pluripotency of the epiblast, the tissue that gives rise to all fetal lineages. Although Nodal is expressed as early as E3.5 in the mouse embryo, its regulation and functions at pre- and peri-implantation stages are currently unknown. Sensitive...

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PMID: 21047506
DOI: 10.1016/j.ydbio.2010.10.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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