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Article

Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation.

Development (Cambridge, England) - 7 Jan 2021

Probst Simone, Sagar, Tosic Jelena, Schwan Carsten, Grün Dominic, Arnold Sebastian J

Abstract excerpt

Anterior mesoderm (AM) and definitive endoderm (DE) progenitors represent the earliest embryonic cell types that are specified during germ layer formation at the primitive streak (PS) of the mouse embryo. Genetic experiments indicate that both lineages segregate from Eomes-expressing progenitors in response to different Nodal signaling levels. However, the precise spatiotemporal pattern of the emergence of these...

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PMID: 33199445
DOI: 10.1242/dev.193789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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