The eed mutation disrupts anterior mesoderm production in mice.

Abstract excerpt

Mouse embryos homozygous for the mutation embryonic ectoderm development (eed) exhibit a growth defect and fail to gastrulate normally. While extraembryonic mesoderm is produced extensively, very little embryonic mesoderm is detected in eed mutant embryos, and there is no subsequent organization of mesoderm into node, notochord, or somites. The phenotype is consistent with a defect in the distal primitive streak....

Topics

• Animals
• Embryonic Induction
• Gastrula
• Gene Expression
• Genetic Markers
• Germ Cells
• Immunohistochemistry