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Article

Failure of hairpin-ended and nicked DNA To activate DNA-dependent protein kinase: implications for V(D)J recombination.

Molecular and cellular biology - 1 Nov 1998

Smider V, Rathmell W K, Brown G, Lewis S, Chu G

Abstract excerpt

V(D)J recombination is initiated by a coordinated cleavage reaction that nicks DNA at two sites and then forms a hairpin coding end and blunt signal end at each site. Following cleavage, the DNA ends are joined by a process that is incompletely understood but nevertheless depends on DNA-dependent protein kinase (DNA-PK), which consists of Ku and a 460-kDa catalytic subunit (DNA-PKCS or p460). Ku directs DNA-PKCS...

Topics

Animals
DNA
DNA Nucleotidyltransferases
DNA-Activated Protein Kinase
DNA-Binding Proteins
Enzyme Activation
Mice
Mice, SCID
Mutation
Nucleic Acid Conformation
Protein Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

VDJ Recombinases

Source

Open in PubMed Open full text

Identifiers

PMID: 9774698
DOI: 10.1128/MCB.18.11.6853
PMCID: PMC109268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Failure of hairpin-ended and nicked DNA To activate DNA-dependent protein kinase: implications for V(D)J recombination.PMID 9774698Read ↗

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Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines.Semantic proximity Read ↗

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