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Article

V(D)J recombination catalyzed by mutant RAG proteins lacking consensus DNA-PK phosphorylation sites.

Molecular immunology - 1 Dec 1999

Lin J M, Landree M A, Roth D B

Abstract excerpt

The process of antigen receptor gene rearrangement, V(D)J recombination, involves DNA cleavage by the RAG-1 and RAG-2 proteins. Cleavage generates covalently sealed (hairpin) DNA ends, termed coding ends, which must be opened by an endonuclease prior to joining. Resolution of these hairpin ends requires the activity of the DNA-dependent protein kinase (DNA-PK), a protein kinase whose specific role is yet...

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Identifiers

PMID: 10684966
DOI: 10.1016/s0161-5890(99)00099-1

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