Article
Double strand break rejoining by the Ku-dependent mechanism of non-homologous end-joining.
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Jan 2000
Jeggo P, Singleton B, Beamish H, Priestley A
Abstract excerpt
The DNA-dependent protein kinase functions in the repair of DNA double strand breaks (DSBs) and in V(D)J recombination. To gain insight into the function of DNA-PK in this process we have carried out a mutation analysis of Ku80 and DNA-PKcs. Mutations at multiple sites within the N-terminal two thirds of Ku80 result in loss of Ku70/80 interaction, loss of DNA end-binding activity and inability to complement Ku80...
Topics
- Animals
- Cell Line
- Cricetinae
- DNA Repair
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Mice
- Mutation
- Protein Serine-Threonine Kinases
- Recombination, Genetic
- Sequence Homology, Nucleic Acid