Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 1996

Blunt T, Gell D, Fox M, Taccioli G E, Lehmann A R, Jackson S P, Jeggo P A

Abstract excerpt

DNA-dependent protein kinase (DNA-PK) consists of a heterodimeric protein (Ku) and a large catalytic subunit (DNA-PKcs). The Ku protein has double-stranded DNA end-binding activity that serves to recruit the complex to DNA ends. Despite having serine/threonine protein kinase activity, DNA-PKcs falls into the phosphatidylinositol 3-kinase superfamily. DNA-PK functions in DNA double-strand break repair and V(D)J...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line

Share to DNA-Binding Proteins

Share to DNA Primers

Share to Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 8816792
DOI: 10.1073/pnas.93.19.10285
PMCID: PMC38376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.PMID 8816792Read ↗

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes.Semantic proximity Read ↗

Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.Semantic proximity Read ↗

PRKDC mutations in a SCID patient with profound neurological abnormalitiesSemantic proximity Read ↗

DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break RepairSemantic proximity Read ↗

Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency miceSemantic proximity Read ↗

Double strand break rejoining by the Ku-dependent mechanism of non-homologous end-joining.Semantic proximity Read ↗

Cloning and chromosomal mapping of the mouse DNA-dependent protein kinase gene.Semantic proximity Read ↗

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect.Semantic proximity Read ↗

DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia.Semantic proximity Read ↗

SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency.Semantic proximity Read ↗

The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic CellsSemantic proximity Read ↗

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.